Abstract. The article presents the results of own research on the study of the incidence of osteoporosis and osteopenia in men with different levels of uric acid and the influence of hyperuricemia on the mineral density of bone tissue. The aim of the study was to examine the structural and functional state of bone tissue (indicators of mineral density) in men with different levels of uric acid and to establish the incidence of osteoporosis and osteopenia in patients with hyperuricemia.

Materials and methods of research. 140 men aged 50–80 years were examined. Determination of the level of uric acid in the serum was performed using the uricase-peroxidase method. Determination of bone mineral density was performed by DXA on the device «Prodigy».

Results. It has been established that the incidence of osteoporosis and osteopenia in men with hyperuricemia is lower compared to men with normouricemia. When dividing by age groups 50–59 years, 60–69 years, 70–79 years in men with hyperuricemia, osteoporosis was detected only in the age group 70–79 years and its incidence was 14% at the level of the lumbar spine (L1–L4) and 14% at the level of the femoral neck (Neack Mean). According to the quarterly distribution according to the level of uric acid, men with the highest level of uric acid had the highest indicators of bone mineral density.

Conclusions. Patients with a high level of uric acid have high levels of bone mineral density, so they are less likely to develop diseases such as osteoporosis and osteopenia, which indicates the protective role of uric acid for bone tissue and may be of practical importance when deciding on the issue of drug correction of hyperuricemia.

Article recieved: 28.08.2023

Keywords: osteoporosis, osteopenia, hyperuricemia, uric acid, bone mineral density

Full text: PDF (Ukr)

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