Introduction. Diabetes is a leading cause of global morbidity and mortality. As genetic inheritance is involved in the pathogenesis of the disease, polymorphism of various genes and genetic mutations could be implicated in the phenotype of the disease manifestation. Recently studies on inheritance of type 2 diabetes mellitus have revealed the observation that the offspring of diabetic parents have forewarning findings of altered neural and autonomic functions even in their non-diabetic state. Therefore, this study has been designed to assess any change in nerve conduction parameters of the motor component of the median nerve in the same population. Objectives. To assess the median motor nerve conduction parameters in non-diabetic offspring of type 2 diabetic and non-diabetic parents and infer the changes in the study population by comparing the groups mentioned above.

Material and Methods. The Nerve conduction study of the median nerve (motor component) was carried out on both hands of 60 non-diabetic volunteers aged between 18-25 (30 offspring of type 2 diabetic parents and 30 offspring of non-diabetic parents with equal number by gender in each group) in normal BMI range.

Results. The comparison between the groups revealed no significant difference in latency, amplitude and conduction velocity in the motor component of the median nerve.

Conclusion. In our study we have observed that there is no significant difference in the motor nerve latencies between the groups. Unlike the observations of altered visually evoked potentials and autonomic impairment in similar population by other studies, the observation of non-involvement of the somatic nerve could be discussed as a sequel to glycation of neural structures that could impair the neuronal activity.

Recieved: 14.12.2017

Ключові слова: motor nerve conduction, offspring of Type 2 diabetic parents

Повний текст: PDF (Eng)

1. 1. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes care. 2004 Jan 1;27 (suppl 1). S.5-10. doi.org/10.2337/diacare.27.2007.S5
2. 2. Anitha Achuthan, Janani Ramesh. Pattern Visual Evoked Potential in Non-Diabetic offsprings of Type II Diabetes. JMR 2015; 1(3):83-86.
3. 3. Brownlee M. The pathobiology of diabetic complications. Diabetes. 2005 June 1;54(6):1615-25. doi.org/10.2337/diabetes.54.6.1615
4. 4. Daube JR, Rubin DI. Nerve conduction studies. //Aminoff's Electrodiagnosis in Clinical Neurology. 6th ed. China: Elsevier Saunders Inc., 2012: 2906.
5. 5. Garg R, Kumar A, Dhar U. A Study of Median Nerve Conduction Velocity in Diabetes Mellitus Type 2 in Neurologically Asymptomatic Patients. International Journal of Health Science and Research. 2013; 3(5):42-9.
6. 6. Gaulton KJ. Mechanisms of type 2 diabetes risk loci. Current diabetes reports. 2017. Sep 1;17(9):72.
7. 7. Goldfine AB, Beckman JA, Betensky RA, Devlin H, Hurley S, Varo N et al. Family history of diabetes is a major determinant of endothelial function. Journal of the American College of Cardiology. 2006. June 20;47(12):2456-61.
8. 8. Gruden G, Cavallo-Perin P, Olivetti C, Repetti E, Sivieri R, Bruno A, Pagano G. Albumin excretion rate levels in non-diabetic offspring of NIDDM patients with and without nephropathy. Diabetologia. 1995. Oct 1;38(10):1218-22.
9. 9. Hasan M, Mohieldein AH, Almutairi FR. Comparative study of serum 8-hydroxydeoxy-guanosine levels among healthy offspring of diabetic and non-diabetic parents. International Journal of Health Sciences. 2017. Jul;11(3):33.
10. 10. Khatri Anshu, Aggarwal Tanu, Changotra Parshant. Heart Rate Variability In Non Diabetic Offsprings Of Type 2 Diabetic Patients. Journal of Advance Researches in Biological Sciences, 2013, Vol. 5 (2). P. 139-43.
11. 11. Klein BE, Klein R, Moss SE, Cruickshanks KJ. Parental history of diabetes in a population based study. Diabetes Care. 1996; 19 (8): 827-30. doi.org/10.2337/diacare.19.8.827
12. 12. Marianne AB van der Sande, Gijs EL Walraven, Paul JM Milligan, Winston AS Banya, Sana M Ceesay, Ousman A Nyan, Keith PWJ McAdam. Family history: an opportunity for early interventions and improved control of hypertension, obesity and diabetes. Bulletin of the World Health Organization, 2001. 79 (4):321-8.
13. 13. Misra UK, Kalita J. Nerve conduction study. Clinical Neurophysiology. New Delhi, Elsevier; 1999: 29-30.
14. 14. Refaat R, Abdelhameed AM, Elbarbary NS, El-Hilaly RA. Evaluation of median nerve in children with type1 diabetes using ultrasonographic imaging and electrophysiology. The Egyptian Journal of Radiology and Nuclear Medicine. 2013. September 30;44(3):563-72.
15. 15. Said G. Diabetic neuropathy-a review. Nature clinical practice Neurology. 2007. June 1;3(6):331-40.
16. 16. Sharma VK, Joshi MV, Vishnoi AA. Interrelation of retinopathy with peripheral neuropathy in diabetes mellitus. Journal of Clinical Ophthalmology and Research. 2016. May 1;4(2):83.
17. 17. Sugimoto K, Yasujima M, Yagihashi S. Role of advanced glycation end products in diabetic neuropathy. Current pharmaceutical design. 2008. April 1;14(10):953-61.
18. 18. Vague P, Dufayet D, Coste T, Moriscot C, Jannot MF, Raccah D. Association of diabetic neuropathy with Na/K ATPase gene polymorphism. Diabetologia. 1997. April 1;40(5):506-11.
19. 19. World Health Organization. Diabetes, Factsheet Internet. Geneva: World Health Organization. 2017. November.
20. 20. Wy So, Mcy Ng, Sc Lee, T. Sanke, H. K. Lee, J.C.N Chan. Genetics of type 2 diabetes mellitus. HKMKJ. 2000. 6:69-76.