One hundred fifty four healthy men in age of 20 to 45 years were examined. The first group (45 probands) performed the short-term physical exertions with 35 % and 50 % intensity of appropriate maximum oxygen consumption. The second group (27 probands) underwent the short-term physical exertions with 75 % and 100 % intensity of appropriate maximum oxygen consumption. The third group comprised of 82 healthy people with the hereditary predisposition to the ischemic heart disease and short-term physical exertions with 35 % and 50 % intensity of appropriate maximum oxygen consumption.

Alteration of adrenaline and noradrenaline excretion and noradrenaline/adrenaline ratio (% NA/A) in healthy people with different 17-ketogenic steroids excretion types in rested state and in short term physical exertion of different intensity were estimated. The results of the study revealed the fact that individuals with hereditary predisposition to the ischemic heart disease demonstrated lower initial adrenaline and noradrenaline excretion levels if compared to the individuals without hereditary predisposition to the ischemic heart disease. In the group with lower 17-ketogenic steroids excretion level, the initial levels of adrenaline and noradrenaline were lower by 41 % and 56 % respectively (p < 0,05) then in the first group.

In rested condition ketogenic steroids excretion type did not affect noradrenalin to adrenalin ratio in all examined groups.

Estimation of average adrenaline and noradrenaline levels after physical exertion revealed significant individual variability of these markers.

Obtained data reveals a reliable increasing of adrenaline and noradrenaline excretion levels by 62 % and 87 % respectively (p < 0,05) in the third group with higher 17-ketogenic steroids growth level. Individuals with the hereditary predisposition to the ischemic heart disease in a subgroup with lower 17-ketogenic steroids level demonstrate a lower adrenaline and noradrenaline indicators if compared to the corresponding subgroups of the first and the second groups.

Considering the research results, it is possible to claim that healthy people with the hereditary predisposition to the ischemic heart disease with higher level of 17-ketogenic steroids excretion have more distinct activation of sympathoadrenal system. However, tense functioning of sympathoadrenal system in individuals of this group with lower initial ketogenic concentration is provided mainly by mediator component of the sympathoadrenal system.

Evaluation of the alteration dynamics of adrenaline and noradrenaline in physical exertion and their ratio allows to detect hormonal and mediator links of the sympathoadrenal system that support the immediate stage of the physical adaptation in healthy people with the hereditary predisposition to the ischemic heart disease. Two types of sympathoadrenal system reactions in response to the physical exertion were observed. It is stated that the higher level of 17-ketogenic steroids excretion in healthy people corresponds to the tens functioning of sympathoadrenal system with activation of both hormonal and mediator links.

Short-term, low intensity physical exertion in poorly trained healthy people with the hereditary predisposition to the ischemic heart disease with lower level of ketogenic supply induces tension of adrenal glands functional reserves. This results in lower adrenaline and noradrenaline excretion growth rate mainly in mediator link of sympathoadrenal system.

Keywords: physical exertion, adaptation, adrenal glands, catecholamine, 17-ketogenic steroids

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1. 1. Andrushko I. Risk factors of atherosclerosis in healthy young subjects with an aggravated heredity of cardio-vascular diseases, depending on the presence of concominant hyperhomocysteinemia. Buc. Med. Herald. 2011;15(4):3-7.
2. 2. Gurinovich H. The influence of active games of the sympato-adrenalin status of junior deaf children. Visnyk of L'viv univ. Biology series. 2006;11:118-122.
3. 3. Gromnatska N. Risk factors of arterial hypertension in children and adolescents. Medical practice. 2005;2:119-125.
4. 4. Korutko Z. On the mechanism of adaptation of cardiovascular system to cyclic loading. Achievements of Biology and Medicine. 2010;2 (16):70-74.
5. 5. Korinchyk L. Effect of physical activity of mental and cardiac function of youth . Sportyvny visnyk Prydniprovya. 2004;7:147-149.
6. 6. Kulachkovsky Y, Mar'yenko B. Defining of 17-ketogenic steroids in urine. Problems of Endocrinology. 2004;7:147-149.
7. 7. Lapovets L. Functional state of the hypophysio-adrenal system in healthy people under the influence of physical loading . Laboratory Diagnostics. 2006;1: 26-28.
8. 8. Levchtenko V, Karabamovich P, Vasilyeva L. Neurohormonal and hemodynamics provision of exercise at girls with manifestation neurocirculatory dystonias. Slobozhanskyi Herald of Science and Sport. 2013;4(37):38-41.
9. 9. Manzhulovskiy V, Muhammed A, Lukasevich I. Cardiovascular Diseases: Current Problems, Treatment, Rehabilitation and Prevention. Theory and Methods of Physical Education and Sports. 2011;2:72-75.
10. 10. Makovetska T, Kovalchuk L. Value of Hereditary Predisposition in Realisation of Peptic ulcer in women . Galician Medical Journal. 2005;1:49-51.
11. 11. Matlina E, Pukhova T, Galilov S. Catecholamine metabolism in muscle activity adaptation. Physiol. Journal. 1976;62(3):431-437.
12. 12. Menschykov V. About catecholamine measurement in urine. Lab. delo. 1961;4:18-21.
13. 13. Polianska O, Kurtian T, Shypitsyana L. Treadmill exercise test assessment of exercise performance. Buc. Med. Herald. 2005;9(1):27-31.
14. 14. Yavors'kyi O, Detsyk Y. Measurement method of adrenaline and noradrenaline in urine. Probl. Pathol. in experiment and clinic. Lviv: 1988. 10. 136.
15. 15. Bartalucci A, Ferucci M, Fulceri F. High-intensity exercise training produces morphological and biochemical changes in adrenal gland of mice. Histol Histopathol. 2012;27(6):753-769.
16. 16. Feldman P, Cohen S, Lepore S. Negative emotions and acute physiological responses to stress. Ann. Behav. Med. 1999;21(3):216-222.
17. 17. Kalinski M. Catecholamine metabolism and signal transduction during exercise. Krakow: Medicina Sportiva; 2000. 144.
18. 18. Norymbersky Y, Sturd R, West H. Assessment of adrenocortical activity by assai of 17-ketogenic steroid in urine. Lancet. 1955;264(6774):1276-1281.
19. 19. Scharz L, Rindermann W. Beta-endorfin, adrenosaarland corticotropic hormonae, cortisoale and catecholamines during aerobic and anaerobic exercise. Europ. J. Appl. Physiol. Uccup. Physiol. 1990;61(3-4):165-171.