Results of investigation of cytokines content – interleukine-6 (IL-6) and transforming growth factor of β1 type (TGF-β1) – during complex treatment of generalized periodontitis of various degree of severity are presented. Various combinations of the osteoplastic materials with osteotropic preparations of different origin were included in treatment schemes of patients from the basic group divided into 4 subgroups. Subgroup 1 included patients who refused surgical treatment and were treated traditionally by means of local therapy. Patients of subgroup 2 were treated with the osteoplastic material ″CollapanL®″ and medication ″Vitrum® Osteomag″. Subgroup 3 received the osteoplastic material ″Easy GraftТМ″ and medication ″Osteogenon″, while subgroup 4 – osteoplastic material ″Osteoplast″ and medication ″Teraflex®″. Control group included individuals with intact periodontium. The level of cytokines – IL-6 and TGF-β1 – was measured in blood serum of patients depending on their gender, severity of pathological process in the periodontal tissues, and seasonal factor at taking blood.

Patients distribution by gender did not reveal statistically valid differences in the level of cytokines in norm and at the generalized periodontitis. While the effect of seasonal factor has demonstrated that TGF-β1 content in blood serum of male and female with intact periodontitis at CSY (cold season of year) was 2 times higher than the indicator measured at WSY (warm season of year). The level of the IL-6 did not show such a big difference in those groups of patients. At the generalized periodontitis the level of TGF-β1 in men at CSY was almost 2 times higher than in women. At the same time, at WSY the level of TGF-β1 in blood serum of men decreased significantly, while in women it was not changed. The content of the IL-6 in blood serum of men and women was approximately on the same level. That indicator was not changed depending on seasonal factor – at CSY and WSY. The analysis of dynamics of indicators of cytokines (IL-6 and TGF-β1) revealed their changes in direction to the norm, and that tendency was not dependent upon the degree of severity of pathological process in the periodontal tissues, peculiarities of its development, age and sgender of patients, and seasonal factor. The peculiarities of changes in the level of studied cytokines during administration of various treatment schemes for generalized periodontitis were detected. The closest normalization was demonstrated for the content of studied cytokines after treatment of the patients of subgroup 4. Thus, among suggested treatment schemes of complex therapy that included combination of the osteotropic medications with the osteoplastic materials of various origins, application of medications based on glycosaminoglycanes most effectively promoted normalization of indicators of studied cytokines – TGF-β1 and IL-6.

Ключові слова: generalized periodontitis, treatment, glycosaminoglycanes, TGF-β1, IL-6

Повний текст: PDF (Ukr)

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