Objective: the studies were aimed at investigating and evaluating peculiar features of changes in spectrum fatty acid of lipids plasma and blood erythrocytes in suffering from caseousus pneumonia, unaffected by the consequences of the Chernobyl accident.

Materials and methods. Were examined 103 (62,4 %) healthy people (group І) and 62 (37,6 %) patients with caseousus pneumonia, unaffected by the consequences of the Chernobyl accident (group ІІ). Fatty-acid composition of plasma lipids in suffering from caseousus pneumonia to study by the biochemical method using a gas-liquid chromatograph “Cvet – 500”.

Results and discussion. The results obtained showed disorders in metabolism of higher fatty acids of lipids plasma and blood erythrocytes in suffering from caseousus pneumonia, unaffected by the consequences of the Chernobyl accident. In both healthy persons fatty-acids spectrum of lipids demonstrated unidirectional in lipids plasma and blood erythrocytes. In patients with caseousus pneumonia, unaffected by the consequences of the Chernobyl accident, fatty-acids spectrum demonstrated unidirectional changes in their ratio both of lipids plasma and blood erythrocytes: we noted a significant elevation in total saturated fatty acid at the expense against a background of an reduction in total unsaturated fatty acids as well and total polyunsaturated fatty acid contents.

Conclusions. A comparative analysis of individual fatty acid contents, total saturated fatty acid contents, total unsaturated fatty acid contents and total polyunsaturated fatty acid contents of lipids plasma and blood erythrocytes іn patients with caseousus pneumonia, unaffected by the consequences of the Chernobyl accident, determines the greater sensitivity of erythrocytes to lipid per oxidation and indicated a possibility for the reliable use of blood erythrocytes as a non-invasive biological object for stydying lipid turnover.

Keywords: fatty acid, plasma, blood erythrocytes, caseousus pneumonia, unaffected by the consequences of the Chernobyl accident

Full text: PDF (Ukr)

1. 1. Baraboi V, Sutkovoy D ; ed. Zozulya Yu. Oxidation-antioxidant homeostasis in normal and pathological. Kiev: Chernobyl-Interinform; Naukova Dumka. 1997;1: 203.
2. 2. Bialik J. Topical issues chemotherapy of patients with multi resistant destructive pulmonary tuberculosis.Tuberculosis, Lung diseases, VІL-іnfection. 2011;1:13-19.
3. 3. Gichka S, Bryuzgina T, Vretik G, Reva S. Gas chromatographic method for determination of lipid indicators of blood in ischemic heart disease. Ukrainian Journal of Cardiology. 1998;7-8:50-52.
4. 4. Zubar N. Fundamentals of physiology and hygiene of feed. Kiev : Center. uchb. l-ry; 2010. 336.
5. 5. Krasiuk V. Co-infection : HIV / AIDS with tuberculosis and hepatotropic viruses. A fresh perspective on complex issues. Тuberculosis, pulmonary disease, HIV infection. 2014;3(18):74-79.
6. 6. Pyatnochka I. Efficacy of treatment pulmonary tuberculosis patients depending on the condition of the bronchial tree. Ukrainian pulmonological Journal. 2009;1:17-21.
7. 7. Rybakova E, Sidelnikov V, Bryuzgina T, Kravchenko E. Method of gas chromatographic determination of lipids in the exhaled breath condensate. Information letter. 1991. 2.
8. 8. Rybakova E, Sidelnikov V, Bryuzgina T, Kravchenko E. The spectrum of fatty acids and levels of free cholesterol in exhaled breath condensate. Laboratory case. 1991;4:74-75.
9. 9. Sazonenko L, Vitovsky Yа, Briuzgina T. Studying lipid parameters in the blood serum of pregnant women with preeclampsia in the dynamics of treatment. Medical chemistry. 2003;1:86-88.
10. 10. Smolar V. Nutritional factors lipid. Problems of nutrition. 2003;1:12-18.
11. 11. Petrenko V, Cherenko S, Litvinenko N et al. Tuberculosis with extended resistance to anti-TB drugs : the situation in Ukraine.Ukrainian pulmonological Journal. 2007;3:35-39.
12. 12. Tuberculosis in Ukraine (analytical and statistical information for 2000–2011). Kiev: 2012. 97.
13. 13. Feschenko Y, Melnyk V. Organization treatment of tuberculosis. Kiev: Health; 2009. 487.
14. 14. Feschenko Y, Cherenko S, Barbova A. Tuberculosis with extended resistance: epidemiological aspects, diagnosis and treatment of problems. Ukrainian pulmonological Journal. 2013;3:31-33.
15. 15. Feshenko Y, Cherenko S, Bialik J et al. Efficiency of hospital treatment of patients with drug-resistant tuberculosis at the time of completion of the intensive phase of chemotherapy. Ukrainian chemotherapeutic Journal. 2010;1-2:33-37.
16. 16. Tb fact sheet, WHO. http://www.who.int / mediacentre /factsheets / fs 194/ en/ index. html. Accessed 28.07.13.