One of the most common infectious diseases causing significant negative impact on public health is hepatitis B virus. By prevalence of HBV infection Ukraine takes one of the first places in Europe. Thus, the incidence of disease is on average 32,5 per 100 thousand of population. Over the last 10–15 years there has been an increase in the overall incidence of HBV infection due to latent forms.

Major indicators characterizing the functional state of the liver in pregnant women with hepatitis B are presented in the article. The level of main enzymes and proteins reflecting the liver disorders was examined in pregnant women with HBV infection including alanine aminotransferase, aspartate transaminase, gamma-glutamyltransferase, thymol test, total protein, effective concentration of albumin and albumin-globulin ratio for the prevention of perinatal complications and long-term effects of viral influence on the woman’s liver in the future. Revealed abnormalities indicate the presence of endogenous intoxication, cytolysis and disorder of protein-synthesizing liver function.

The aim of the work was the development and introduction of an efficient algorithm for diagnosis of hepatic function in pregnant women with HBV-infection. 80 women were examined in term of 28–40 weeks of pregnancy. The main group consisted of 40 pregnant women with НВV-infection and the control group consisted of 40 apparently healthy pregnant women with uncomplicated pregnancy. Clinical and biochemical indicators were determined in the blood serum of the pregnant woman in fasting state. They included thymol test, total protein, effective albumin concentration (EAC), albumin-globulin ratio (A/G ratio), alanine aminotransferase (ALT), aspartate transaminase (AST), gammaglutamyl transferase (GGT).

In the study of the women in the main group were significantly higher performance levels of thymol test 2,4 times, 2,23 times alanineaminotransferase, aspartateaminotransferase 2,6 times and 3,35 times in GGT, while lowering the levels of total protein 13,4 % effective concentration of albumin by 42,8 % and albunino-globulin coefficient – 10,8 %.

Surveys showed early onset of disturbances of liver function in patients with viral hepatitis B in history. Hepatic dysfunction was observed during the detailed examination of pregnant women with HBV infection in comparison with a group of healthy pregnant women. Changes of indicators of protein-synthesizing liver function were detected, mainly hypoproteinemia with simultaneous hypergammaglobulinemia. Increase in thymol test level was also observed, indicating to dysproteinemia. All this indicates disorder of colloid blood stability and to a tendency of protein coagulation. Assessing liver enzymatic function increase in transaminase level was found indicating histochematic barrier breach with simultaneous cytolytic syndrome. Increase in the level of gamma-glutamyltransferase was observed in most examined pregnant women with hepatitis B signaling the presence of endogenous intoxication in women of this category. An examination of pregnant women with HBV infection detected significant abnormalities. Thus, detailed biochemical screening allows beginning adequate therapy, to prevent perinatal complications and the development of remote negative impact of the virus on the liver in the future.

Keywords: HBV infection, pregnant women, liver, gamma-glutamyltransferase

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