Overview of this article is devoted to the justification to demonstrate how biologically active substances in citrus are applied in dentistry. The article substantiates the main advantage, impact and basic functions of various types of citrus fruits which are used in medicine, and how the citrus bioflavonoid extracts not only in diseases of various human organs and systems, but also in dental practice, due to the advantage of these biologically active substances on the drug chemical origin. With therapeutic and prophylactic proposes citrus fruits and their leaves, flowers, seeds, juice and peel of the fruit have been used for a long time. Nowadays in medicine and dentistry most commonly are used citrus fruits that contain a very large number of different compounds, especially mono and disaccharides, pectin, essential oils, organic acids and vitamins. Regarding the effects of citrus essential great content of poliphenols – bioflavonoids today these substances are considered as the most important bioregulators of plant origin. Citrus bioflavonoids possess a wide spectrum of important biological functions, among which are anti-inflammatory, osteotropic, capillarystressed, antispasmodic and antitoxic. Citrus fruit bioflavonoids also are potent antioxidants. It has been experimentally and clinically proven that there is high efficiency of citrus fruit extracts in medicine usage, particularly in endocrinology, gastroenterology and others. Data about such high positive efficiency led to further study and use of extracts of citrus fruits in dentistry. In particular local application of quercetin in various forms alveolitis, stomatitis and generalized periodontitis. Widespread use in the complex treatment of inflammatory and degenerative diseases of periodontal mouthwash acquired from citrus bioflavonoids that have parodontoprotecting, antioxidant and anti-inflammatory properties, and have a high advantage over drugs of chemical origin. New dentistry has many chemical drugs, but their functions are rather negative, and their long-term use in patients causes side effects. That is why more attention is paid to herbal products, namely bioflavonoids, especially in plant of citrus extracts. Products of citrus bioflavonoid are much better. In the treatment of periodontal patients different bioflavonoid contains form of drugs, films, mouthwash and other active and positive forms, especially in periodontal dentistry are used. Biologic active forms are very popular in medicine and dentistry now, because they have best perspective in experimental and clinical treatment. With the change of the environment bioflavonoids of extract citrus plants have become very important in the treatment of dental diseases, especially in periodontolgy practice. This enables us to approve the application of this medicine and recommend using biologically active substances of citrus fruit in dentistry.

Ключові слова: citrus, citrus biologically active substances, bioflavonoids, therapeutic and preventive influence

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1. 1. Levitskij A, Pochtar V, Makarenko O, Gridina L. Antioxidant-prooxidant index blood serum of rats with experimental stomatitis and its correction mouthwash. Odes'kij Medicnij Zurnal. 2006;6:22-25.
2. 2. Vialatel Kl. Use of solutions for mouthwash in daily practice. Pharmacy. 2001;16(287):3.
3. 3. Borisenko A, Chesnokova A, Oginskaya L et al. The impact of the application of quercetin in complex treatment of generalized periodontitis on lipid pereoxidation. Medical Problems. 1999;7-8:54-56.
4. 4. Dereyko L, Babych N, Babych T. Organization and management of maintenance treatment in patients with periodontal disease in dental practice. Novyny Stomatologiy. 2004;2:20-23.
5. 5. Dorkina E. Study of hepatoprotective action of natural flavonoid compounds. Experimental and Clinical Pharmacology. 2004;67(6):41-44.
6. 6. Yeliseyeva N. Phytherapy in dentistry. Stomatolog. 2006;7:22-29.
7. 7. Mirchuk B, Drogomyretska M, Den'ga O, Levitskij A. Fitoadaptoheniv use in dentistry (Literature Review). Visnyk Stomatologiy. 2007;2:62-66.
8. 8. Zayachkivska O. The impact of calcitonin-peptide hens to extract the kernels hastroprotective induced grapefruit. Experimental and Clinical Physiology and Biochemistry. 2005;4:43-47.
9. 9. Levitskij A. The nutritional factors in the pathogenesis, prevention and treatment of dental diseases. Visnyk Stomatologiy (spec. issue). 2005;2:5-7.
11. 11. Levitskij A. Bioflavonoids as regulators of physiological functions. Visnyk Stomatologiy. 2001;1:71-76.
12. 12. Levitskij A, Makarenko O, Pustovojt E. The influence mouthwash "Mandarinovyj" on the antioxidant-prooxidant status of the oral mucosa of rats with peoxidation stomatitis. Visnyk Stomatologiy. 2007;3:7-10.
13. 13. Levitskij A. The digestive enzymes of the salivary glands: autoref. dis. doctor biolog. sciences: ….. . Odessa, 1974. 53.
14. 14. Melnichuk G. The generalized periodontitis and periodontal disease: markers of genetic predisposition the pathogenic mechanisms of metabolic disorders and their complex correction: autoref. dis. doctor med. sciences. Odessa, 2008. 33.
15. 15. Mashenko I, Skidan K, Levitskij A, Lisnichuk M. The microbiological and neuroendocrine aspects of pathogenetic treatment of periodontitis. Visnyk Stomatologiy. 2007;4:140-141.
16. 16. Perova M, Fomicheva E, Fomicheva A. The recession periodontal tissues. Modern state of question. New in Dentistry. 2005;5:38-45.
17. 17. Danilevskiy V, Fedorov U, Blohin V, and others. The use mouthwash on the basis of biologically active substances in the treatment and prevention of periodontal disease. Stomatology (spec. issue). 1996;52-53.
18. 18. Pustovojt E, Skiba V, Rossahanova L. The influence "Grapefruit" mouthwash on the antioxidant system of the oral mucosa with experimental stomatitis. Visnyk Stomatologiy. 2007;2:20-23.
19. 19. Guzhevska N, Politun A, Moshcych O, Gritsenko O. The regulators of metabolic disorders and immunity in the treatment in generalized periodontitis. Liky. 1999;3-4:136-139.
20. 20. Skiba V, Pochtar V, Goloborodko V, et al. The regulation dysbiosis of oral cavity bioflavonoids. Visnyk Stomatologiy (spec. issue). 2006;3:27-28.
21. 21. Ryabokon E, Hudyakova M, Cherepinska U. Quercetin application in medicine and dentistry. Stomatolog. 2010;4(143):48-52.
22. 22. Hadarcev А, Eskov V, Dedov V [and others]. Theory and practice of regenerative medicine. Adaptogens in medical and biological systems. Tula: M.:Infra, 2005. 220.
23. 23. Cimbalistov A, Robakidze N. Pathophysiological aspects development pathology of the mouth and gastrointestinal tract. Dentistry for all. . 2005;1:28-34.
24. 24. Chumakova U. Pathogenic gastification complex methods of treatment generalized periodontitis: autoref. dis. doctor med. sciences. Odessa, 2008. 37.
25. 25. Shevchuk S. The effect of bioflavonoids on the toxicity of methotraxsate in combination with adjuvant arhtritis in leflupomidome. Liky Ukrainy. 2003;2:26-28.
26. 26. Yakovleva L, Mishenko O. Activity score stresprotective new pharmacological tools adaptoghenic action of the model of acute immoboilization stress. Visnyk Farmaciy. 2006;2(46):60-63.
27. 27. Andersen O, Markham K. Flavonoids: chemistry, biochemistry and applications. Taylor and Francis CRC Press. 2005. 1256.
28. 28. mediated oxidation of LDL and attennate atherogenesis. Atherosclerosis. 1998;37(1):45-50.28. Aviram P, Fubrman B. Polyphenolic flavonoids inhibibit macrophage doi.org/10.1016/S0021-9150(97)00306-7
29. 29. Blakson H, Gratterod E, Seglen P. Prevention of toxin-induced cytoskeletal disruption and apoptic liver cell death by grapefruit flavonoid, naringin. Cell Death Differ. 2000;7:739-746. doi.org/10.1038/sj.cdd.4400705
30. 30. Engelhart M, Geerlings M, Ruitenberg A, Swieten J, Hofman A, Witteman J et al. Dietary intake of antioxidants and risk of Alzheimer desease. JAMA. 2002;287(24):3223-3229. doi.org/10.1001/jama.287.24.3223
31. 31. Mastragelopulos N, Haraszty V, Zambon J, Zafiropolos G. Erste Beweise einer intressanten Beziehung parodontitus und Gafässerkrankungen. Dentalhygiene J. 2001;2:31-37.
32. 32. Feng Z, Weinberg A. Role of bacteria in health and disease of periodontal tissues. Periodontology 2000. 2006;40:50-76. doi.org/10.1111/j.1600-0757.2005.00148.x
33. 33. Ashida H, Fukuda I, Yamashita T, Kanazawa K. Flavones and flavonols at dietary levels inhibit a transformation of aryl hydrocarbon receptor induced by dioxin. FEBS Lett. 2000;476(3):213-217. doi.org/10.1016/S0014-5793(00)01730-0
34. 34. So J, Guthrie N, Chambers A, Moussa M, Caroll K. Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenegis by flavonoids and citrus juics. Nutr. Cancer. 1996;26:167-181.
35. 35. Çetin E, Buduneli N, Atlihan E, Kirilmaz L. In vitro studies of degradable device for controlled-release of meloxicam. J. Clin. Periodontol. 2005;32:773-777.
36. 36. Kroyer G. The antioxidant activity of citrus fruit peels. Z. Ernahrungswis. 1986;25:63-68.
37. 37. Lamson D, Brignall M. Antioxidants and cancer. Part 3: quercetin. Altern. Med. 2000;5:196-208.