Ninety healthy men at the age from 20 to 45 years were examined. The first group (25 probands) performed short-term physical exertions with 35% and 50% intensity of appropriate maximum oxygen consumption. The second group (20 probands) underwent short-term physical exertions with 75% and 100% intensity of appropriate maximum oxygen consumption. The third group comprised healthy people with the hereditary predisposition to the ischemic heart disease. The third group of 45 probands performed short-term physical exertions with 35% and 50% intensity of appropriate maximum oxygen consumption.

Changes in the level of cortisol in blood and relationship between 17-ketosteroids in urine and level of cortisol in blood in healthy people with hereditary predisposition to the ischemic heart disease under the influence of short-term physical exertion were examined. The results of the study revealed the fact that the level of cortisol in blood in all groups of examined healthy people did not differ in the rested state.

Short-time physical exertion in healthy people of the first and second groups led to decrease of the cortisol level in blood immediately after exertion by 7,35% (p>0,05) and 13,5% (p=0,08). One hour after physical exertion the level of cortisol in healthy people of first and second groups significantly decreased by 46,6% and 22,5% respectively (p<0,05). Short-term physical exertions with 35% and 50% intensity of appropriate maximum oxygen consumption in healthy people with hereditary predisposition to ischemic heart disease were accompanied by the elevation of the cortisol level in blood. One hour after the physical exertion the level of cortisol was reduced by 33,27% (p<0,05). Our study revealed poor correlation between the level of cortisol in blood and excretion magnitude of 17-ketosteroids, 17-ketogenic steroids, and main components of urine 17-ketosteroids in all groups of the probands, in the rested state. A substantial correlation of the changes in the level of cortisol and the changes of 17-ketosteroids active metabolite androstenedione (r=+0,79) in healthy people after the short-term intensive physical exertion was revealed. A strong correlation in the alteration of the cortisol level and etioholanolon (one of the active metabolite intermediate form) (r=+0,60) was estimated in healthy people as a result of the short-term physical exertions with 35% and 50% intensity of appropriate maximum oxygen consumption.

During the investigation, a short-term growth of the cortisol level in blood accompanied by a decrease of androgen active metabolite androstenedione in 17–ketosteroids composition was detected.

Results of the research indicate tense functioning of the adrenal cortex reserves in healthy people with the hereditary predisposition to the ischemic heart disease under short-term physical exertion.

Assessment of the changes in the level of cortisol in blood and estimation of the correlation between the compounds of the 17-ketosteroids in urine under the physical exertion allows to reveal a hormonal supply of the immediate stage of the physical adaptation in healthy people with the hereditary predisposition to the ischemic heart disease.

Ключові слова: physical exertion, adrenal glands, corticosteroids, androgens, cortisol, androstenedione, 17-ketogenic steroids

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