In recent decades the issue of drug addiction has appeared to be not only a social but primarily a medical problem. Enormous use of drugs substances and the prevalence of substance abuse observed in recent decades make it necessary to study the effect of opioids on the structural organization of organs and systems.

This scientific work presents data analysis of professional literature on the morphological changes of body tissues while drug use. Chronic opioid poisoning causes profound lethargy of overall body reactivity and resistance against various infectious processes, forms chronic endogenous intoxication with natural development of multiple organ failure (MOF).

Significant metabolic changes, early disability and mortality of patients with opioid abuse require a study of pathogenetic mechanisms of multiple organ comorbid conditions progression.

Since the drug interacts with opiate receptors, which are associated with the placement of cell membrane lipids, the basis for nerve cells and opioid receptors dysfunction is the change in the structural and metabolic characteristics of lipoprotein membranes under conditions of opioid abuse. Imbalance in lipid metabolism is a typical result of narcotic intoxication. The imbalance is concentrated in the brain, blood, liver, lungs and is caused by disorders of energy metabolism that may have undesirable destructive effect on the structure of biological membranes.

Studying the structure of blood vessels and its walls histostructuire in normal state and under the influence of various factors allow to deeply explore the importance of vascular factors in the morphofunctional failure of internal organs. It is a well known fact that each function is based on its adequate structure. Vessels of microcirculatory bed are among the first to respond to pathogenic factors of structural changes and make the basis for the development of the pathological process determining its nature and characteristics of clinical features.

Macroscopically affected organs resemble the situation of chronic inflammatory diseases. Thus the internal organs suffer from uneven blood filling, most blood vessels are spasmodic with mostly liquid and dark blood along with occasional loose clots. This work presents data analysis that allow to identify the substantial restructuring of the hepatobiliary system, depending on the drug dose and the severity of addiction. Regularity of specific changes in terms of internal organs and the state of cardiovascular system in patients with opioid addiction in terms of pathogenesis was found.

Distinctive somatic features during the drug use, have been found, and in this process the leading role of cardiovascular system pathology in this process have been concluded.

According to the opinions of some individual authors the increased drug use leads to the release of histamine active inflammatory mediator and the development of allergic reactions. In addition, the data presented in the paper proves that immune pathogenetic factor causes atypical and progressive infection along with its rapid generalization and organ damage.

Thus, the problem of opioid substances influence on organs and systems restructuring is both actual and important to modern medicine. Many questions concerning the structural changes of tissues while drug use remain unresolved in the application of drugs, remain unresolved. Professional literature data on this subject are contradictory and require clarification.

Keywords: structural organization, narcotic substances

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