Summary. Introduction and aim. Previously, in the process of implementing the project «Sexual differences in the parameters of the neuroendocrine-immune complex and the state of neuroendocrine-immune relationships in intact rats and exposed to stressors and adaptogens», we analyzed such relationships for the entire sample. The aim of this study is to analyze neuroendocrine-immune relationships in intact rats of both sexes.

Material and methods. We calculated the parameters of the HRV: Mode, Amplitude of the mode and Variational scope as markers of the circulating catecholamines, sympathetic and vagal tones respectively. Among endocrine parameters determined serum levels of main adaptation hormones such as Corticosterone, Aldosterone, Testosterone, Triiodothyronine, as well as Parathyroid hormone and Calcitonin. The percentage of lymphocyte populations and the parameters of phagocytosis by neutrophils and monocytes of Staphylococcus aureus were determined in the blood. The Thymus and Spleen were weighed and made smears-imprints for counting Thymocytogram and Splenocytogram.

Results. The canonical correlation between neuroendocrine and immune variables was analyzed. According to the levels of the coefficient of determination R2, neuroendocrine factors were ranked in the following order: corticosterone (0.983), testosterone (0.869), catecholamines (0.846), sympathetic tone (0.845), triiodothyronine (0.833), PTH (0.748), vagal tone (0.641), calcitonin (0.641), and aldosterone (0.627).

Conclusion. There is a close canonical correlation between registered neuroendocrine factors and immunity parameters in intact rats.

Keywords: adaptation hormones, HRV, thymus, spleen, immunocytes of blood, phagocytosis, relationships, male and female rats

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