Abstract. Experimental and clinical findings regarding hypocoagulation induced by various colloid substances, hypertonic crystalloids, and polyatomic alcohols in the literature are conflicting due to variations in doses and physicochemical properties of specific solutions across different studies.

Aim. To investigate the mediated effect of a multicomponent protein-salt hyperosmolar solution on hemostasis in an experimental study on white rats.

Methods. The protein-salt hyperosmolar solution under the laboratory code AXAM was studied, composed of 5 % donor albumin, xylitol, sodium acetate, malate, and electrolytes Na+, K+, Ca++, Mg++, and Cl–; the theoretical osmolarity of the solution was approximately 640 mOsm/L. The study was conducted on male white rats divided into experimental and control groups, each consisting of 10 animals. The experimental group received intra-abdominal injections of AXAM at a dose of 10 ml/kg daily for 30 days. No manipulations were performed on the control group. Blood samples were collected from the animals at the end of the study for analysis. Screening coagulation tests and thromboelastography (TEG) were conducted for a comprehensive assessment of the hemostatic system.

Results. No statistically significant differences were observed in the indicators of screening coagulation tests between the experimental and control groups (p > 0.05). The analysis of parameters utilizing the comprehensive hemostasis assessment method, thromboelastography (TEG), revealed that fundamental parameters such as reaction time (R), clotting time (K), α-Angle, maximum amplitude (MA), and coagulation index (CI) in both the control and experimental groups did not exhibit statistically significant variations (p > 0.05). Furthermore, there were no discernible distinctions between the groups (p > 0.05) in the value of G, indicative of clot density and quality. Notably, clot lysis within 30 minutes was not observed in either group of animals.

Conclusion. The repeated intraperitoneal administration of the proteinsalt hyperosmolar solution AXAM at a dose of 10 ml/kg daily for 30 days does not elicit statistically significant changes (p > 0.05) in the blood coagulation system in experimental rats.

Ключові слова: albumin, hyperosmolar solutions, protein-salt infusion preparations, hemostasis, thromboelastography

Повний текст: PDF (Ukr)

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